|
KMID : 1134820070360050548
|
|
Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 5 p.548 ~ p.553
|
|
|
The Effect of Herbal Formula KH-305 on Erectile Dysfunction in Hyperlipidemic Rat
|
|
Lee Eun-Jeong
Kim Hee-Seok
Kim Byoung-Chul
Hwang Sung-Wan
Hwang Sung-Yeoun
|
|
|
Abstract
|
|
|
|
This study was designed to investigate effects of KH-305 on erectile dysfunction in hyperlipidemic rat. KH-305 has been evaluated for antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high cholesterol-diet. After oral administration of KH-305 water extract (50, 100, 200, 300 ㎎/㎏) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL-, and LDL-cholesterol levels in serum, the expression of eNOS and nNOS in penis were measured. Also, erectile function was determined by the measurements of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-305 extracts significantly inhibited the increase of serum total cholesterol and LDL-cholesterol levels and the decrease of serum HDL-cholesterol level in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzymes (eNOS, nNOS) were increased significantly after oral administration of the KH-305 extracts. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-305 group compared with hyperlipidemic group. These results suggest that KH-305 is effective for erectile dysfunction in hyperipidemia.
|
|
|
KEYWORD
|
|
|
erectile dysfunction, hyperlipidemia, ICP
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|